Telegraph Process: Two-State Switching

A continuous-time Markov chain flipping between two states — the simplest model of gene expression bursting, ion channel gating, and signal noise

Switching Rates

Telegraph Process
λ: ON→OFF rate (dwell time ~ Exp(λ))
μ: OFF→ON rate (dwell time ~ Exp(μ))

Stationary dist: P(ON)=μ/(λ+μ)
Mean = μ·hi + λ·lo)/(λ+μ)
Variance = λμ(hi-lo)²/(λ+μ)²

Power spectral density (Lorentzian):
S(f) ∝ 1/[(λ+μ)² + (2πf)²]

Diffusion limit: Brownian motion
The telegraph process is the canonical two-state noise model. In gene expression, promoter switching between active/inactive states creates transcriptional bursts. In neuroscience, ion channels toggle between open and closed. The Lorentzian power spectrum is its fingerprint — a flat (white) plateau below the corner frequency λ+μ.