STOCHASTIC GENE EXPRESSION
Burst size b
5
Burst freq α (hr⁻¹)
2.0
Decay rate δ (hr⁻¹)
0.5
Feedback strength f
0.0
Cells N
500
Mean ⟨m⟩
—
Var(m)/⟨m⟩
—
CV²
—
Mode(s)
—
Burst model (Raj et al 2006):
ON→burst of b mRNAs at rate α
Degradation: mRNA → ∅ at rate δ
Stationary dist: Negative Binomial
P(m)=NB(α/δ, 1/(b+1))
⟨m⟩=αb/δ, Fano=b+1
Feedback: α→α/(1+f·m)