Splicing Modes
Constitutive splicing
Exon skipping
Alt donor site
Alt acceptor site
Intron retention
Mutually exclusive
Neuronal splicing
Muscle splicing
Default pattern
Alternative Splicing Code
Spliceosome assembles on pre-mRNA, recognizing splice sites. ESEs (exonic splicing enhancers) and ESSs guide exon choice. One gene → many protein isoforms. Tissue-specific RBPs control the code.
mRNA Isoforms from this gene:
Constitutive exon
Alternative exon
Intron
Spliceosome (snRNPs)
ESE / splice enhancer
ESS / splice silencer