Master seq freq
—
Error threshold μ_c
—
Current μ·L
—
Phase
—
Mean fitness
—
Eigen (1971): quasispecies equation
dxᵢ/dt = Σⱼ Qⱼᵢ fⱼ xⱼ − φxᵢ
Error threshold: μ_c = ln(A)/L
Above threshold: uniform distribution — information erased.
Relevance: RNA viruses operate near this threshold, maximizing evolvability.
dxᵢ/dt = Σⱼ Qⱼᵢ fⱼ xⱼ − φxᵢ
Error threshold: μ_c = ln(A)/L
Above threshold: uniform distribution — information erased.
Relevance: RNA viruses operate near this threshold, maximizing evolvability.