Protein Folding Energy Landscape

Proteins fold by navigating a rugged free-energy funnel landscape. The "new view" (Wolynes, Bryngelson) replaces the Levinthal paradox with a funnel picture: evolution has sculpted landscapes with a global minimum (native state) accessible without exhaustive search.

5.0
3.0
5
Energy
Q (nativeness)
Folded?
Steps
0