⟨PROTEIN AGGREGATION⟩
Monomer concentration
0.60
Nucleation rate k_n
0.002
Growth rate k_+
0.50
Dissociation k_-
0.05
Secondary nucleation
0.001
RESET
Monomers:
-
Aggregates:
-
Total fibrils:
-
Mean size:
-
Lag time:
-
Aggregation kinetics
(Oosawa-Asakura): Monomers nucleate slowly (rate k_n·[M]^n), then grow rapidly (k_+·[M]). Secondary nucleation (fibril-catalyzed) creates autocatalytic acceleration — sigmoidal kinetics with a lag phase. Relevant to amyloid diseases (Alzheimer's, Parkinson's).