Protein Aggregation — Amyloid Nucleation-Growth

Kinetics of amyloid fibril formation via primary nucleation, elongation, and secondary nucleation (Knowles-Waudby model). Sigmoidal kinetics with lag phase.

Kinetic Parameters

Primary nucleation k_n: 1e-4 Elongation k_+: 1.0 2° Nucleation k_2: 1e-3 Total monomer m_tot: 5.0 n_c (nucleus size): 2

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Lag time t_lag—

t½—

Final mass frac—

Max fibrils P—

Protein Aggregation — Amyloid Nucleation & Growth

Kinetic Parameters

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