Intrinsic vs Extrinsic Noise

Intrinsic noise σ_i 0.30

Extrinsic noise σ_e 0.20

Mean expression μ 1.00

Correlation time τ 10.0

η²_tot = —

η²_int = —

η²_ext = —

Fano(CFP) = —

Fano(YFP) = —

Dual reporters: CFP (cyan) and YFP (yellow) driven by identical promoters in same cell. Extrinsic noise = correlated. Intrinsic = independent.