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Network Motifs & Feed-Forward Loops
Milo et al. 2002 · 3-node subgraph census · transcription network overrepresentation
3-Node Directed Motifs
Z-score = (count_real - μ_random) / σ_random
Red = overrepresented in biological nets
New Random Network
Load Bio Network
Count Motifs
Click "Count Motifs" to analyze subgraphs
Feed-Forward Loop Dynamics
Input signal
0.5
AND / OR threshold
0.6
Time delay τ
8
C1-FFL (coherent): sign-sensitive delay.
X→Y→Z and X→Z (AND gate at Z).
Sign-off delay: Z off only after X off long enough.
C1-FFL
I1-FFL
Step Input
Pulse