Network Motifs
Subgraph significance · Z-scores vs random ensembles · Feed-forward loops
Network (click to rewire)
3-Node Motif Catalog
Real vs Random counts (Z-score)
Nodes
16
Edge Prob
0.20
Rand Samples
30
New Network
Z-score:
Z = (N
real
− ⟨N
rand
⟩) / σ
rand
Feed-forward loop:
A→B→C, A→C (abundant in gene networks)
Significance:
|Z| > 2 → over/under-represented motif