Metabolic Network Flow

Animated flow through the core metabolic network. Particles represent flux through pathways. Glycolysis breaks glucose into pyruvate; the Krebs cycle extracts energy as ATP. Adjust enzyme activities to bottleneck or accelerate the pathway.

ENZYME ACTIVITY

Hexokinase (HK) 0.8 Phosphofructokinase (PFK) 0.7 Pyruvate Kinase (PK) 0.9 Citrate Synthase (CS) 0.8 NADH Dehydrogenase 0.7

ATP yield / cycle

Science: Flux balance analysis: at steady state, S·v = 0 where S is stoichiometric matrix and v is flux vector. PFK is the major allosteric control point (inhibited by ATP, activated by AMP). Theoretical max: 36–38 ATP per glucose.

METABOLIC NETWORK FLOW

ENZYME ACTIVITY