Hydrophobic Effect — Water Solvation Shell

Entropy-driven aggregation · iceberg water structure · ΔS dominates at room T

Simulation

Exposed surface:
ΔG_solv ~ kT
Structure water:
Key physics: Hydrophobic solutes don't "repel" water — water is repelled by losing H-bond partners. The solvation shell water is more ordered (lower entropy).

Thermodynamics: ΔG = ΔH − TΔS. At room T, TΔS dominates: clustering reduces total ordered water, increasing entropy → spontaneous aggregation.

Scale: γ ≈ 25 cal/mol/Ų for small solutes. Oils have ~20 Ų per CH₂ → ΔG ≈ 0.7 kcal/mol per group.

Blue dots = ordered "iceberg" water; white = bulk water