The HP (Hydrophobic-Polar) lattice model: protein folds to maximize hydrophobic contacts, minimizing free energy.
Presets:
Energy: -Best: -Steps: 0Accepted: -
H (hydrophobic, red) residues gain energy -1 for each non-bonded H-H neighbor contact. P (polar, blue) residues have no energy. Monte Carlo with VSHD moves (pivot + crankshaft) explores conformational space. Lower temperature → more greedy folding.