Flux Balance Analysis — Metabolic Network

Animated flux flow through a simplified 6-node glycolytic pathway with ATP yield optimization

ATP yield: 0 mol/mol-glc Lactate: 0.00 Mode: aerobic
About: Flux Balance Analysis (FBA) finds steady-state metabolic fluxes that maximize a cellular objective (typically ATP or biomass production) subject to stoichiometric constraints and flux bounds. In this simplified network, glucose is phosphorylated to G6P, enters glycolysis producing pyruvate and ATP, then feeds the TCA cycle (aerobic) or is converted to lactate (anaerobic). O₂ availability controls the aerobic/anaerobic switch — Warburg effect in cancer cells shifts toward lactate even with O₂.