Epigenetic Controls
Normal environment
Starvation stress
Toxin exposure
Enriched environment
Next Generation →
Reset to Gen 0
Transgenerational Epigenetic Inheritance
Epigenetic marks survive fertilization and are transmitted to offspring. Some marks are reset; others escape erasure and carry environmental memory across generations.
DNA methylation (inherited)
H3K27me3 (inherited)
H3K4me3 (reset)
Stress mark (new)
piRNA-mediated
G0
Normal
Inherited marks:
0