Heterogeneous Mixing — Core Group Epidemics

Two-group SIR with assortative mixing: high-risk core drives transmission

Population Structure

Two-group SIR mixing matrix:
β_ij = β·[(1−q)δ_ij + q/N_j]
Effective R₀ = ρ(next-gen matrix)
Core threshold: p_c·R₀_c > 1
Targeted vaccination of core
highly efficient (Yorke 1978)
R₀ effective:
Core infected:
Gen. infected:
Final size: