On heterogeneous networks, the epidemic threshold depends on degree heterogeneity: R₀ = β/γ · ⟨k²⟩/⟨k⟩ (Pastor-Satorras & Vespignani 2001). For scale-free networks (P(k)∝k−γ), ⟨k²⟩ diverges, making the threshold vanish — epidemics spread for any β>0. Herd immunity requires vaccinating fraction 1 − 1/R₀ of the population.