DNA Melting Bubbles — Poland-Scheraga Model

Poland-Scheraga model for DNA thermal denaturation. GC base pairs (stronger, 3 H-bonds) and AT pairs (weaker, 2 H-bonds) create a heterogeneous sequence with a complex melting profile. Watch breathing bubbles open as T rises.

Temperature T (°C): 70

GC fraction: 0.50

Chain length N: 80

Cooperativity σ: 0.001

Open fraction θ—

Tm (°C) est.—

# open bubbles—

GC pairs open—