Codon Usage Bias
Synonymous codons are not used equally. High-expression genes prefer codons matching abundant tRNAs.
tRNA Adaptation Index (tAI): 0=random, 1=perfectly optimized.
GC3 = GC content at 3rd codon position — strongest bias signal.
Synonymous codons are not used equally. High-expression genes prefer codons matching abundant tRNAs.
tRNA Adaptation Index (tAI): 0=random, 1=perfectly optimized.
GC3 = GC content at 3rd codon position — strongest bias signal.