Chromatin Remodeling
ATP-dependent nucleosome sliding by SWI/SNF and ISWI complexes
Remodeling Controls
Add Nucleosome
SWI/SNF Remodel
ISWI Space Evenly
Eject Nucleosome
Reset
ATP Budget
ATP:
100
%
Nucleosomes:
3
Open bp:
0
Mode:
Idle
Biology
SWI/SNF: ~1 MDa complex
Smarca4/BRG1 ATPase
Slides or ejects nucleosomes
ISWI (NURF/CHRAC):
Spaces nucleosomes evenly
Linker DNA sensing by AutoN
ATP hydrolysis pumps
DNA around the octamer
~10-25 bp/ATP