Cell Cycle Network — Tyson Model

Controls

Cell mass m = 1.0 k1 (Cdk1 synth) = 0.15 k3 (APC act) = 1.0

Cdk1: —

APC: —

Phase: —

dC/dt = m·k1 − k2·C − k3·A·C
dA/dt = k4·C·(1−A) − k5·A

C = Cdk1/MPF activity
A = APC/Cdh1 activity

Low C → G1 (growth)
Rising C → S phase
High C → G2/M (mitosis)
APC peak → cell division

Limit cycle = cell cycle!

Cell Cycle Network — Tyson's Model

Controls