Balancing Selection
Overdominance maintains polymorphism — sickle cell anemia, ABO blood groups, MHC diversity
Fitness Parameters
w(AA) homozygote 1:
0.85
w(Aa) heterozygote:
1.00
w(aa) homozygote 2:
0.75
Starting frequency p₀:
0.50
Population size:
1000
Generations:
200
Run Simulation
Run 10 Replicates
Equilibrium p*:
—
Final p:
—
Mean fitness:
—
Sickle cell example: AA=0.85 (malaria risk), Aa=1.0 (protected), aa=0.65 (sickle cell disease). Equilibrium is maintained in malaria regions.
Allele Frequency
Phase Portrait
Fitness Landscape