Active Gel — Actomyosin
Contractility-Driven Pattern Formation in the Cell Cortex
Running…
Active gels model the actin–myosin cortex: a polar, out-of-equilibrium fluid where ATP-driven
myosin motors generate internal stresses. The order parameter is the local actin density ρ(x,y,t).
The simplified model: ∂ρ/∂t = D∇²ρ − ∇·(ζρ²∇ρ) + η,
where ζ is the active contractility (motors pulling actin toward high-density regions).
Above a critical ζ, the homogeneous state is unstable — actin condenses into clusters, rings,
and cortical waves seen in dividing cells. This active-matter instability is distinct from
passive phase separation; energy is continuously injected by ATP hydrolysis.